
Reilly was born in Chicago, Illinois, son of an Irish American Father and a Lithuanian American mother. He is an alumnus of DePaul University in Chicago.
To date, Reilly has appeared in more than fifty films, including three separate films in 2002 (all three were nominated for the Academy Award for Best Picture). He has been nominated for An Academy Award for Best Supporting Actor for his role in Chicago and a Grammy Award for the song, “Walk Hard,” Which he performed in Walk Hard: The Dewey Cox Story.